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tissue microarray
Tissue microarrays (also TMAs) consist of paraffin blocks in which up to 1000〔(Yale University Core Tissue MicroArray Facility )〕 separate tissue cores are assembled in array fashion to allow multiplex histological analysis.
==History==
The major limitations in molecular clinical analysis of tissues include the cumbersome nature of procedures, limited availability of diagnostic reagents and limited patient sample size. The technique of tissue microarray was developed to address these issues.
Multi-tissue blocks were first introduced by H. Battifora in 1986 with his so-called “multitumor (sausage) tissue block" and modified in 1990 with its improvement, "the checkerboard tissue block" . In 1998, J. Kononen and collaborators developed the current technique, which uses a novel sampling approach to produce tissues of regular size and shape that can be more densely and precisely arrayed.
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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